Tag Archives: Pharmacy and cosmetology

Preparation of innovative hydrogel wound dressings based on poly(acrylic acid)

Katarzyna BIALIK-WĄS, Bożena TYLISZCZAK, Edyta WILK, Krzysztof PIELICHOWSKI ? Department of Chemistry and Technology of Polymers, Faculty of Chemical Engineering and Technology, Cracow University of Technology, Cracow, Poland Abstract: This paper describes new method of preparation of poly(acrylic acid) ? based hydrogel materials under microwave irradiation. The application of poly(ethylene glycol) (PEG), biodegradable and non-toxic polymer, which is widely used in medicine and pharmacy, enabled to control the degree of swelling and degradation of poly(acrylic) matrix. The obtained acrylic hydrogels modified by PEG were investigated towards: swelling ability in distilled water, 0.9% of NaCl solution and 0.9% of MgCl2 solution, degradation in simulated body fluids (SBF and Ringer?s solution) and the thermal stability by thermo-gravimetric analysis (TGA). Please cite as: CHEMIK 2013, 67, 2, 99-104 1. Introduction Nowadays polymers are widely applied as biomedical materials, because they have the following characteristics: biocompatibility, biophosphates, bioactivity, non-toxicity, chemical resistance. Among them important groups represent the hydrogels, whose dynamic development began in 1960. The great turning point was the...
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Synthesis and interaction with albumin of N,N-dimethylaminbenzyl derivative of thiosemicarbazone and its ruthenium(II) complex

Michał ŁOMZIK, Małgorzata BRINDELL ? Inorganic Chemistry Department, Faculty of Chemistry, Jagiellonian University, Cracow, Poland Abstract: Previous studies have shown that some thiosemicarbazones have antitumor activity as inhibitors of ribonucleotide reductase and their reactivity can be enhanced by coordination to Ru ion. The following paper describes the synthesis of N,N-p-dimethylaminbenzaldehyde thiosemicarbazone and its Ru(II) complex. In addition, the interaction of the obtained compounds with albumin was carried out using fluorescence spectroscopy. It has been shown that coordination of ligand to ruthenium decrease its reactivity towards albumin and therefore the better bioavailability is expected. Please cite as: CHEMIK 2013, 67, 2, 91-98 Introduction Cancer is defined as a group of diseases characterized by uncontrolled cell division. As a result, the growth of tumour tissue is observed, and very often it leads to an impairment of an organ on which the tumour is growing. One of the main problem in anticancer therapy is the variety of cancer types. Therefore, it is difficult to design a universal drug....
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Nanocarriers in medicine

Justyna SIEMIENIEC ? Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wroclaw, Poland Abstract: Each traditional drug introduced into the body is causing various side effects. This usually results from low specificity, difficulties in reaching its destination, and fast metabolism. To prevent this, in order to improve the biodistribution of the drug, reduce side effects and thus improve the quality of life of patients, intensive research on the use of nanotechnology developments in medicine is carried out. Drug nanocarriers, metal nanoparticles or polymer capsules are the most commonly used for this purpose. Additionally, to ensure effective treatment, rapid and accurate medical diagnosis is equally important. In this field the quantum dots with their specific optical properties closely connected with the size of the order of nanometers attract specific attention. Please cite as: CHEMIK 2013, 67, 2, 83-90 Introduction In 1959, Professor Richard Feynman at the congress of the American Physical Society delivered a lecture entitled ?There is a plenty of room...
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Rosemary ? a plant rich in biologically active compounds

Krystyna NOWAK, Małgorzata JAWORSKA, Jan OGONOWSKI Institute of Chemistry and Organic Technology, Cracow University of Technology, Cracow, Poland Abstract: The aim of this study is to present the characteristics of biologically active compounds contained in the rosemary (such as rosemary oil, flavonoids, terpenes, phenolic acids) and their use in pharmaceutical, cosmetic and food industries. Please cite as: CHEMIK 2013, 67, 2, 133-138 Introduction Rosemary ( Rosmarinus officinalis L.) is an aromatic, evergreen plant which grows in the wilderness on the coasts of Mediterranean Sea and in the southern part of Crimea. In Poland the only possibility is to grow it in a greenhouse. Rosemary used to be well known and grown in the ancient times. The Romes called it a flower of the sea. Its name derives from Latin from words rosa- rose and marinus ? nautical. The well smelled scent of rosemary on the seas indicated the moment of approaching a shore. The most recognizable herbalist of Middle Ages, Saint Hildgerard from Bingen...
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Comparison of the effectiveness of antibacterial effect of disinfectants on microorganisms isolated from the epidermis

Aleksandra ZIEMBIŃSKA, Marta SZPINDOR - Environmental Biotechnology Department, The Silesian University of Technology, Gliwice, Poland Abstract: Chemical disinfectants are commonly used in households, working places, educational centres etc. However, due to the fast increase of microorganisms? resistance to chemical compounds used in this type of preparations, it is important to choose a suitable and effective disinfectant that prevents bacterial infections in a fast and efficient way. In this study, an attempt was taken to estimate the effectiveness of chemical disinfection preparations: iodine tincture, solutions of salicylic alcohol, oxidized water and potassium permanganate on the autochthonous microflora of the human epidermis.  Studies have revealed that iodine tincture is the most effective, while a 0.05% solution of potassium permanganate the least effective against bacteria isolated from the epidermis. Other preparations have demonstrated a surprisingly high effectiveness. Please cite as: CHEMIK 2013, 67, 2, 127-132 Introduction The concept of disinfection includes techniques of microorganisms control by chemical means and of their mechanical removal. Most, but not all,...
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Influence of kind and concentration of emulsifiers from the group of polyethoxylated fatty acids sorbitol esters on the rheological properties of Crodamol PC-based nanoemulsions

Małgorzata JAWORSKA, Elżbieta SIKORA, Jan OGONOWSKI ? Institute of Chemistry and Organic Technology, University of Technology, Cracow, Poland Abstract: The aim of this work was the preparation and rheological characterization of o/w nanoemulsions stabilized by polysorbates, containing Crodamol PC as the oil phase. The formulations were prepared by phase inversion composition method. Measurements of the internal phase droplets size were carried  out using Malvern Zetasizer apparatus. The rheological properties of the emulsions systems were studied by using Brookfield rheometer, Model - R/S Plus. The obtained results confirmed that the prepared nanoemulsions showed non-Newtonian, pseudo-plastic behavior. Please cite as: CHEMIK 2013, 67, 2, 119-126 Introduction The effectiveness of cosmetic products depends largely on their physicochemical form. A relatively new form of cosmetic products is nanoemulsions, liquid dispersion systems of internal phase particles size of 20 ? 500 nm. Particles of nanoemulsions are too small to scatter visible light, which makes them optically transparent or translucent. Due to its properties (a large interfacial surface area, low...
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Comparison of quantitative determination of ?-tocopherol acetate in pharmaceutical preparations by microemulsion electrokinetic chromatography and ultrafast liquid chromatography

Dariusz WIDEŁ, Jerzy OSZCZUDLOWSKI, Zygfryd WITKIEWICZ ? Institute of Chemistry Jan Kochanowski University, Kielce, Poland; Marcin MOCZULSKI ? Comesa Polska Sp. z o.o., Beckman Coulter Biotechnology Division, Warszawa, Poland Abstract: In the present work microemulsion electrokinetic chromatography (MEEKC) was applied for quantitative determination of vitamin E in ?-tocopherol acetate form. Capillary electrophoresis system with diode array detector was used to perform the analysis. Microemulsion consists of: 10 % (w/w) SDS, 6.6  % (w/w) 1-butanol, 0.8 % (w/w) n-octane, 12.5 % (w/w) 2-propanol, 40% (w/w) phosphate buffer with pH=2.5 and 30.1 % (w/w) demineralized water, was used in capillary. The quantitative determination of vitamin E was performed with the external standard method with the use of the 32 Carat ver.  8.0 software from Beckman Coulter Inc. Additionally the quantitative determination of the vitamin E by ultrafast liquid chromatography (UFLC) method was performed for the purpose of the comparison of results with the MEEKC method. Please cite as: CHEMIK 2013, 67, 2, 111-118 1. Introduction Vitamins are a...
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Development of Commercially Successful Biosensors for Glucose

Edmond MAGNER ? Materials and Surface Science Institute and Department of Chemical and Environmental Sciences, University of Limerick, Limerick, Ireland Abstract: The development and characterization of electrochemical biosensors is described from the perspective of the development of biosensors for the determination of glucose. The factors that have influenced the large scale commercial development of electrochemical glucose biosensors are discussed. Please cite as: CHEMIK 2013, 67, 2, 105-110 Introduction A biosensor is a device that combines a biological recognition element together with a transduction system for the detection of a specific analyte [1]. The biological component can comprise species such as a redox protein or enzyme, an antibody, a whole cell or a DNA strand and serves the purpose of imparting specificity to the sensor. The transduction system transforms the recognition event of the biological component into a measurable signal utilising optical, piezoelectric, conductimetric, thermometric, amperometric or potentiometric methods of detection. The first biosensor, for the measurement of glucose was developed by Clark in 1962...
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Application and characteristics of Achillea millefolium and its oil

Application and characteristics of Achillea millefolium and its oil Krystyna NOWAK, Jan OGONOWSKI, Katarzyna SZULC ? Institute of Organic Chemistry and Technology, Cracow University of Technology, Cracow Please cited as: CHEMIK 2010, 64, 2, 103-110 The work presents the characteristics of yarrow and yarrow essential oil with particular consideration of the chemical composition of the oil and its impact on the biological activity. The significance of these materials in the technology for small-scale production, particularly in pharmaceutical and cosmetic industry. Keywords: Yarrow and yarrow essential oil, properties and application Read more: pdf-icon...
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Lipase ? characterization, applications and methods of immobilization

Lipase ? characterization, applications and methods of immobilization Elwira LASOŃ, Jan OGONOWSKI - Institute of Organic Chemistry and Technology, Cracow University of Technology, Cracow Please cited as: CHEMIK 2010, 64, 2, 97-102 In this paper the characterization of the lipase enzyme was presented, with special consideration to its production and catalytic properties which decide about the wide-ranging applications, as well as about the methods of its immobilization. Keywords: lipase, immobilization, enzyme Read more: pdf-icon...
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